{"id":60926,"date":"2024-02-04T12:00:20","date_gmt":"2024-02-04T09:00:20","guid":{"rendered":"https:\/\/www.turkishpost.net\/ar\/?p=60926"},"modified":"2024-02-04T12:00:20","modified_gmt":"2024-02-04T09:00:20","slug":"kansere-karsi-umut-mrna-asisi","status":"publish","type":"post","link":"https:\/\/www.turkishpost.net\/ar\/kansere-karsi-umut-mrna-asisi\/","title":{"rendered":"Kansere kar\u015f\u0131 umut: mRNA a\u015f\u0131s\u0131"},"content":{"rendered":"

(The Turkish Post) –<\/strong> Do\u011frudan kanser h\u00fccrelerine kar\u015f\u0131 etkili olan bir a\u015f\u0131 hen\u00fcz mevut de\u011fil. Ancak belirli kanser t\u00fcrlerinin geli\u015fmesine yol a\u00e7abilecek enfeksiyonlara kar\u015f\u0131 a\u015f\u0131lanmak m\u00fcmk\u00fcn. T\u0131pk\u0131 papilloma vir\u00fcslerinin (HPV) tetikledi\u011fi rahim a\u011fz\u0131 kanserinin \u00f6nlenmesi amac\u0131yla yap\u0131lan a\u015f\u0131lama gibi.<\/p>\n

Bu kanser t\u00fcr\u00fcne kar\u015f\u0131 \u00f6nleyici a\u015f\u0131lar, 2000’li y\u0131llar\u0131n ba\u015f\u0131ndan beri mevcut. Y\u00fcksek riskli papilloma vir\u00fcs\u00fc enfeksiyonu asl\u0131nda do\u011frudan kansere neden olmaz. Ancak vir\u00fcs, mukoza zar\u0131 h\u00fccrelerine kal\u0131c\u0131 olarak yerle\u015fir ve orada kanser \u00f6ncesi a\u015famalar\u0131n\u0131 tetiklerse, rahim a\u011fz\u0131 kanserine yol a\u00e7abilir.<\/p>\n

Bir ba\u015fka \u00f6nleyici a\u015f\u0131 da hepatit B vir\u00fcslerine ve dolay\u0131s\u0131yla kronik hepatit B durumunda geli\u015febilen karaci\u011fer t\u00fcm\u00f6rlerine kar\u015f\u0131 yap\u0131lan a\u015f\u0131lar. Alman Kanser Ara\u015ft\u0131rmalar\u0131 Merkezi b\u00fcnyesindeki Kanser Bilgi Servisi’ne g\u00f6re, sanayile\u015fmi\u015f \u00fclkelerdeki t\u00fcm kanserlerin yakla\u015f\u0131k y\u00fczde d\u00f6rd\u00fc, vir\u00fcs veya bakteri enfeksiyonlar\u0131ndan kaynaklan\u0131yor. Bu oran geli\u015fmekte olan \u00fclkelerde daha y\u00fcksek.<\/p>\n

Terap\u00f6tik a\u015f\u0131lar<\/strong><\/h4>\n

\u00d6nerilen bu iki \u00f6nleyici a\u015f\u0131n\u0131n yan\u0131 s\u0131ra, yo\u011fun ara\u015ft\u0131rmalara konu olan tedavi edici a\u015f\u0131lar da var. Bunlardan biri olan terap\u00f6tik mRNA a\u015f\u0131s\u0131, mevcut bir kanser hastal\u0131\u011f\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131yor. Covid pandemisi s\u0131ras\u0131nda s\u0131k s\u0131k g\u00fcnde gelen mRNA (haberci ribon\u00fckleik asit) a\u015f\u0131lar\u0131, bilhassa ba\u011f\u0131\u015f\u0131kl\u0131k sistemini t\u00fcm\u00f6r h\u00fccreleriyle sava\u015fmak \u00fczere e\u011fitebiliyor. Bu a\u015f\u0131lar, kanser h\u00fccrelerini alg\u0131lamay\u0131 ve onlar\u0131 h\u0131zl\u0131 bir \u015fekilde ortadan kald\u0131rmay\u0131 \u00f6\u011fretebilir. Bu esnada ortaya \u00e7\u0131kan yan etkilerse nispeten zars\u0131z olarak s\u0131n\u0131fland\u0131r\u0131labilir.<\/p>\n

Alman Kanser Bilgi Servisi’nden Susanne Weg-Remers, bu a\u015f\u0131n\u0131n i\u015fe yaramas\u0131 i\u00e7in belirli ko\u015fullar\u0131n yerine getirilmesi gerekti\u011fini belirtiyor: “Mevcut bilgilere g\u00f6re mRNA a\u015f\u0131lar\u0131, \u00f6zellikle de t\u00fcm\u00f6r dokusu, \u00f6rne\u011fin ameliyatla v\u00fccuttan b\u00fcy\u00fck \u00f6l\u00e7\u00fcde \u00e7\u0131kar\u0131lm\u0131\u015fsa bir se\u00e7enek olabilir. Bu durumda di\u011fer aktif maddelerle birlikte mRNA a\u015f\u0131s\u0131, v\u00fccutta h\u00e2l\u00e2 kalabilecek ve n\u00fcksetmeye yol a\u00e7abilecek kanser h\u00fccrelerini ortadan kald\u0131rmaya yard\u0131mc\u0131 olabilir.”<\/p>\n

Bu nedenle mRNA a\u015f\u0131lamas\u0131, daha fazla hastan\u0131n iyile\u015fme \u015fans\u0131n\u0131 art\u0131rabilir. Bu y\u00f6ntem, doktorlar\u0131n terapiyi t\u00fcm\u00f6r\u00fcn bireysel \u00f6zelliklerine g\u00f6re uyarlamas\u0131na olanak tan\u0131yor. Kansere kar\u015f\u0131 mRNA a\u015f\u0131s\u0131, Sars-CoV-2’ye kar\u015f\u0131 mRNA a\u015f\u0131lar\u0131yla ayn\u0131 tabana dayan\u0131yor.<\/p>\n

T\u00fcm\u00f6r antijenlerinin rol\u00fc<\/strong><\/h4>\n

Kanser h\u00fccreleri genelde y\u00fczeylerinde ya hi\u00e7 bulunmayan ya da sa\u011fl\u0131kl\u0131 h\u00fccrelerde daha az bulunan tipik \u00f6zelliklere sahiptir. Doktorlar, kanser h\u00fccrelerine kar\u015f\u0131 a\u015f\u0131 geli\u015ftirirken “t\u00fcm\u00f6r antijenleri” olarak adland\u0131r\u0131lan bu \u00f6zellikleri kullan\u0131yor. Hastaya, t\u00fcm\u00f6r antijenlerine kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini tetikleyen bir a\u015f\u0131 uygulan\u0131yor. Ama\u00e7, ba\u011f\u0131\u015f\u0131kl\u0131k sistemine bu antijenlere sahip h\u00fccrelere kar\u015f\u0131 kendini savunmay\u0131 \u00f6\u011fretmek. Ara\u015ft\u0131rmac\u0131lar, erken klinik \u00e7al\u0131\u015fmalarda, \u00f6rne\u011fin malign melanomda (siyah cilt kanseri), terap\u00f6tik m-RNA a\u015f\u0131lamas\u0131 ile ba\u015far\u0131lar elde etmeye ba\u015flad\u0131.<\/p>\n

Susanne Weg-Remers, s\u00f6z konusu a\u015f\u0131lara dair \u00e7al\u0131\u015fmalar hakk\u0131nda \u015fu bilgileri veriyor: “Malign melanom mRNA terapisi ile ilgili 2024 y\u0131l\u0131nda, bin hastay\u0131 kapsayan uluslararas\u0131 bir klinik \u00e7al\u0131\u015fma planlan\u0131yor. Bu \u00e7al\u0131\u015fma, ileride ruhsatland\u0131rma i\u00e7in temel olu\u015fturacak. Ara\u015ft\u0131rmalar\u0131n odakland\u0131\u011f\u0131 di\u011fer kanser t\u00fcrleri aras\u0131nda ba\u011f\u0131rsak kanseri ve akci\u011fer kanseri de var. Bunlar, en yayg\u0131n kanser t\u00fcrlerinin ba\u015f\u0131nda geliyor. 200’den fazla kanser t\u00fcr\u00fc ve molek\u00fcler \u00f6zellikleri bak\u0131m\u0131ndan farkl\u0131l\u0131k g\u00f6steren ba\u015fka alt tipler var. T\u00fcm bu farkl\u0131 kanser t\u00fcrlerini bir a\u015f\u0131yla \u00f6nleyebilecek veya tedavi edebilecek sihirli mermiyi bulmak \u00e7ok zor.”<\/p>\n

A\u015f\u0131n\u0131n mucize g\u00f6stermesi beklenmemeli<\/strong><\/h4>\n

Kanser Bilgilendirme Servisi’ne g\u00f6re, sadece Almanya’da her y\u0131l yakla\u015f\u0131k yar\u0131m milyon ki\u015fiye kanser te\u015fhisi konuluyor. Almanya’da 2021 y\u0131l\u0131nda 230 bin insan, bu hastal\u0131ktan hayat\u0131n\u0131 kaybetti.<\/p>\n

Bug\u00fcne kadar elde edilen t\u00fcm ba\u015far\u0131lara ra\u011fmen, ara\u015ft\u0131rmac\u0131lar, kansere kar\u015f\u0131 a\u015f\u0131 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131n\u0131n hen\u00fcz emekleme a\u015famas\u0131nda oldu\u011funa dikkat \u00e7ekiliyor. \u0130lk sonu\u00e7lar, kansere kar\u015f\u0131 a\u015f\u0131laman\u0131n etkili olabilece\u011fini g\u00f6sterse de standart tedavilerle mukayese edilen yayg\u0131n klinik deneyimler hen\u00fcz mevcut de\u011fil.<\/p>\n

Ayr\u0131ca her hastal\u0131\u011f\u0131n ve hastan\u0131n profilinin kendi \u00f6zg\u00fc oldu\u011fu ger\u00e7e\u011fi de yads\u0131namaz.\u00a0 \u00d6rne\u011fin bir hastadan t\u00fcm\u00f6r al\u0131nm\u0131\u015fsa ve v\u00fccutta kalan izole t\u00fcm\u00f6r h\u00fccreleriyle m\u00fccadele edilmesi gerekiyorsa bu, metastaz olu\u015fumuna k\u0131yasla tamamen farkl\u0131 bir tedavi gerektirir. Weg-Remers, “Kanser tedavisinin, etkili sonu\u00e7lar elde etmek i\u00e7in farkl\u0131 y\u00f6ntemlerin bir araya getirildi\u011fi b\u00fct\u00fcnsel bir terapi olmaya devam edece\u011fini d\u00fc\u015f\u00fcn\u00fcyorum” diyor.<\/p>\n","protected":false},"excerpt":{"rendered":"

(The Turkish Post) – Do\u011frudan kanser h\u00fccrelerine kar\u015f\u0131 etkili olan bir a\u015f\u0131 hen\u00fcz mevut de\u011fil. Ancak belirli kanser t\u00fcrlerinin geli\u015fmesine yol a\u00e7abilecek enfeksiyonlara kar\u015f\u0131 a\u015f\u0131lanmak m\u00fcmk\u00fcn. T\u0131pk\u0131 papilloma vir\u00fcslerinin (HPV) tetikledi\u011fi rahim a\u011fz\u0131 kanserinin \u00f6nlenmesi amac\u0131yla yap\u0131lan a\u015f\u0131lama gibi. Bu kanser t\u00fcr\u00fcne kar\u015f\u0131 \u00f6nleyici a\u015f\u0131lar, 2000’li y\u0131llar\u0131n ba\u015f\u0131ndan beri mevcut. Y\u00fcksek riskli papilloma vir\u00fcs\u00fc enfeksiyonu […]<\/p>\n","protected":false},"author":2,"featured_media":60939,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jnews-multi-image_gallery":[],"jnews_single_post":{"source_name":"DW T\u00fcrk\u00e7e","source_url":"https:\/\/www.dw.com\/tr\/kansere-kar%C5%9F%C4%B1-umut-mrna-a%C5%9F%C4%B1s%C4%B1\/a-68163343","via_name":"","via_url":"","override_template":"0","override":[{"template":"1","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"topbottom","share_float_style":"share-monocrhome","show_share_counter":"0","show_view_counter":"0","show_featured":"1","show_post_meta":"1","show_post_author":"0","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"0","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"1","zoom_button_out_step":"4","zoom_button_in_step":"4","show_post_tag":"1","show_prev_next_post":"0","show_popup_post":"1","number_popup_post":"2","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-715","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"107","hide":""},"jnews_override_bookmark_settings":{"override_bookmark_button":"0","override_show_bookmark_button":"0"},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[107,1],"tags":[1433,1612,1422],"class_list":["post-60926","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yasam","category-son-haberler","tag-kanser","tag-mrna-asisi","tag-slider-manset"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/60926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/comments?post=60926"}],"version-history":[{"count":0,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/60926\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media\/60939"}],"wp:attachment":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media?parent=60926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/categories?post=60926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/tags?post=60926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}