{"id":3568,"date":"2023-03-14T13:26:08","date_gmt":"2023-03-14T10:26:08","guid":{"rendered":"https:\/\/www.turkishpost.net\/ar\/?p=3568"},"modified":"2023-03-14T13:26:08","modified_gmt":"2023-03-14T10:26:08","slug":"15-dakikada-migren-agrisini-kesebilen-burun-spreyi-abdde-onaylandi","status":"publish","type":"post","link":"https:\/\/www.turkishpost.net\/ar\/15-dakikada-migren-agrisini-kesebilen-burun-spreyi-abdde-onaylandi\/","title":{"rendered":"15 dakikada migren a\u011fr\u0131s\u0131n\u0131 kesebilen burun spreyi ABD’de onayland\u0131"},"content":{"rendered":"

(The Turkish Post) –<\/strong> ABD G\u0131da ve \u0130la\u00e7 \u0130daresi, yeti\u015fkinlerde migren a\u011fr\u0131s\u0131n\u0131 h\u0131zla giderdi\u011fi belirtilen yeni bir burun spreyini onaylad\u0131.<\/p>\n

ABD’li ila\u00e7 devi Pfizer’\u0131n geli\u015ftirdi\u011fi Zavzpret adl\u0131 ilac\u0131n Temmuz 2023’te eczanelerde sat\u0131\u015fa sunulmas\u0131 bekleniyor.<\/p>\n

\u0130la\u00e7 \u015firketinin ba\u015f ticari yetkilisi Angela Hwang “Zavzpret’in FDA’den onay almas\u0131, a\u011fr\u0131dan kurtulmaya ihtiya\u00e7 duyan ve a\u011f\u0131zdan al\u0131nan ila\u00e7lara kar\u015f\u0131 alternatif se\u00e7enekleri tercih eden migren hastalar\u0131 i\u00e7in \u00f6nemli bir at\u0131l\u0131m” dedi.<\/p>\n

\u0130lac\u0131n klinik deneylerinde baz\u0131 migren hastalar\u0131n\u0131n a\u011fr\u0131s\u0131n\u0131 ve di\u011fer rahats\u0131z edici semptomlar\u0131n\u0131 15 dakika gibi k\u0131sa bir s\u00fcrede kesebildi\u011fi g\u00f6r\u00fcld\u00fc. A\u011fr\u0131 d\u0131\u015f\u0131ndaki migren semptomlar\u0131 aras\u0131nda \u0131\u015f\u0131k hassasiyeti ve mide bulant\u0131s\u0131 da var.<\/p>\n

Halihaz\u0131rda migreni tedavi etmek kullan\u0131lan i\u00e7in birka\u00e7 \u00e7e\u015fit burun spreyi ve bir dizi farkl\u0131 ila\u00e7 t\u00fcr\u00fc mevcut. Zavzpret ise beyinde salg\u0131lanan ve iltihaplanmaya katk\u0131da bulunan bir protein olan kalsitonin geniyle ili\u015fkili\u00a0 CGRP adl\u0131 bir peptidi bloke ederek \u00e7al\u0131\u015f\u0131yor. Spreyin bu t\u00fcrden ilk ila\u00e7 oldu\u011fu ifade ediliyor.<\/p>\n

\u00d6te yandan, CGRP’yi bloke etmek \u00fczere tasarlanm\u0131\u015f a\u011f\u0131zdan al\u0131nan birka\u00e7 hap da var. Ancak migreni olan bir\u00e7ok ki\u015finin ciddi mide bulant\u0131s\u0131 deneyimledi\u011fini ve yutmak zorunda olduklar\u0131 ila\u00e7lar\u0131 tolere edemediklerini belirtiyor.<\/p>\n

Hakemli bilimsel dergi The Lancet Neurology’de yay\u0131mlanan deney sonu\u00e7lar\u0131nda 10 miligraml\u0131k tek bir Zavzpret dozu alan ki\u015filerin yakla\u015f\u0131k 24’\u00fcn\u00fcn semtomlar\u0131n\u0131n yakla\u015f\u0131k iki saat i\u00e7inde kayboldu\u011fu g\u00f6zlemlendi.<\/p>\n

New England N\u00f6roloji ve Ba\u015f A\u011fr\u0131s\u0131 Enstit\u00fcs\u00fc’n\u00fcn t\u0131bbi direkt\u00f6r yard\u0131mc\u0131s\u0131 Kathleen Mullin, ilac\u0131 “h\u0131zl\u0131 ila\u00e7 emilimine sahip bir burun spreyi” diye niteledi.<\/p>\n

Mullin, “Zavzpret, a\u011fr\u0131 kesici ihtiyac\u0131 olan veya mide bulant\u0131s\u0131 veya kusma nedeniyle a\u011f\u0131zdan ila\u00e7 alamayan ki\u015filer i\u00e7in alternatif bir tedavi se\u00e7ene\u011fi sunuyor” diye ekledi.<\/p>\n

Pfizer, Zavzpret’i ge\u00e7en y\u0131l ila\u00e7 \u015firketi Biohaven’dan yakla\u015f\u0131k 10 milyar dolar kar\u015f\u0131l\u0131\u011f\u0131nda \u015firketin di\u011fer migren tedavileriyle birlikte sat\u0131n alm\u0131\u015ft\u0131.<\/p>\n

Migrenlerin d\u00fcnya genelinde insanlar\u0131n y\u00fczde 10’undan fazlas\u0131n\u0131 etkiledi\u011fi tahmin ediliyor. Kad\u0131nlarda erkeklere g\u00f6re yakla\u015f\u0131k \u00fc\u00e7 kat daha yayg\u0131n g\u00f6r\u00fcl\u00fcyor.<\/p>\n

Genellikle kafa b\u00f6lgesinde saatlerce veya g\u00fcnlerce s\u00fcrebilen zonklay\u0131c\u0131 a\u011fr\u0131ya neden olan migren, \u0131\u015f\u0131\u011fa veya sese duyarl\u0131l\u0131k, mide bulant\u0131s\u0131, kusma veya g\u00f6rme bozukluklar\u0131na da sebebiyet verebiliyor.<\/p>\n","protected":false},"excerpt":{"rendered":"

(The Turkish Post) – ABD G\u0131da ve \u0130la\u00e7 \u0130daresi, yeti\u015fkinlerde migren a\u011fr\u0131s\u0131n\u0131 h\u0131zla giderdi\u011fi belirtilen yeni bir burun spreyini onaylad\u0131. ABD’li ila\u00e7 devi Pfizer’\u0131n geli\u015ftirdi\u011fi Zavzpret adl\u0131 ilac\u0131n Temmuz 2023’te eczanelerde sat\u0131\u015fa sunulmas\u0131 bekleniyor. \u0130la\u00e7 \u015firketinin ba\u015f ticari yetkilisi Angela Hwang “Zavzpret’in FDA’den onay almas\u0131, a\u011fr\u0131dan kurtulmaya ihtiya\u00e7 duyan ve a\u011f\u0131zdan al\u0131nan ila\u00e7lara kar\u015f\u0131 alternatif […]<\/p>\n","protected":false},"author":2,"featured_media":3570,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jnews-multi-image_gallery":[],"jnews_single_post":{"source_name":"Independent T\u00fcrk\u00e7e","source_url":"https:\/\/www.indyturk.com\/node\/616701\/sa%C4%9Flik\/15-dakikada-migren-a%C4%9Fr%C4%B1s%C4%B1n%C4%B1-kesebilen-burun-spreyi-abdde-onayland%C4%B1","via_name":"","via_url":"","override_template":"0","override":[{"template":"1","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"topbottom","share_float_style":"share-monocrhome","show_share_counter":"1","show_view_counter":"1","show_featured":"1","show_post_meta":"1","show_post_author":"0","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"0","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"1","zoom_button_out_step":"4","zoom_button_in_step":"4","show_post_tag":"1","show_prev_next_post":"0","show_popup_post":"1","number_popup_post":"2","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-715","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"107","hide":""},"jnews_override_bookmark_settings":{"override_bookmark_button":"0","override_show_bookmark_button":"0"},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[1,107],"tags":[527,526,525],"class_list":["post-3568","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-son-haberler","category-yasam","tag-burun-spreyi","tag-ilac","tag-migren"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/3568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/comments?post=3568"}],"version-history":[{"count":0,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/3568\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media\/3570"}],"wp:attachment":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media?parent=3568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/categories?post=3568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/tags?post=3568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}