{"id":31837,"date":"2023-10-08T10:31:18","date_gmt":"2023-10-08T07:31:18","guid":{"rendered":"https:\/\/www.turkishpost.net\/ar\/?p=31837"},"modified":"2023-10-08T10:31:18","modified_gmt":"2023-10-08T07:31:18","slug":"otopsi-incelemeleri-ortaya-cikardi-kalp-krizi-ve-inme-riskini-artiriyor","status":"publish","type":"post","link":"https:\/\/www.turkishpost.net\/ar\/otopsi-incelemeleri-ortaya-cikardi-kalp-krizi-ve-inme-riskini-artiriyor\/","title":{"rendered":"Otopsi incelemeleri ortaya \u00e7\u0131kard\u0131: Kalp krizi ve inme riskini art\u0131r\u0131yor"},"content":{"rendered":"

(The Turkish Post) –<\/strong> Ge\u00e7ti\u011fimiz g\u00fcnlerde d\u00fcnyan\u0131n en sayg\u0131n t\u0131p dergilerinden Nature Cardiovascular Research\u2019da yer alan bir \u00e7al\u0131\u015fma, korona vir\u00fcs\u00fc enfeksiyonunun sadece kalp damarlar\u0131n\u0131 tutmakla yetinmedi\u011fi, \u00f6zellikle kolesterol plaklar\u0131na ve kolesterolle sava\u015fan h\u00fccrelere bula\u015farak onlar\u0131 rezervuar olarak kulland\u0131\u011f\u0131n\u0131; bunun da kolesterol\u00fc y\u00fcksek olanlarda Covid enfeksiyonu sonras\u0131 artm\u0131\u015f kalp krizi ve inme riskinin 1 y\u0131la kadar uzayabildi\u011fini ortaya koydu. Ayr\u0131ca kolesterolle sava\u015fan savunma h\u00fccrelerini enfekte eden vir\u00fcs\u00fcn, yeni kolesterol plaklar\u0131n\u0131n olu\u015fumunu da tetikledi\u011fi tespit edildi.<\/p>\n

\u00c7al\u0131\u015fma, May\u0131s 2020-May\u0131s 2021 tarihleri aras\u0131nda New York\u2019ta Kovid\u2019den ya\u015fam\u0131n\u0131 yitiren ve kalp tutulumu bilinen 8 ya\u015fl\u0131 hastan\u0131n otopsi incelemeleri sonucu ger\u00e7ekle\u015ftirildi. B\u00f6ylece Sars-Cov2 vir\u00fcs\u00fcn\u00fcn sadece damar tutulumu yapmad\u0131\u011f\u0131, diyabet, hipertansiyon, kolesterol gibi kronik tablosu olan hastalarda, kolesterol plaklar\u0131n\u0131 da tutarak yakla\u015f\u0131k 1 y\u0131l boyunca kalp damar olaylar\u0131 (kalp krizi gibi) ve inme riskini art\u0131rd\u0131\u011f\u0131 belirlendi. \u00c7al\u0131\u015fmay\u0131 de\u011ferlendiren Sancaktepe \u0130lhan Varank E\u011fitim ve Ara\u015ft\u0131rma Hastanesi Kalp Damar Cerrahisi Klinik \u015eefi Prof. Dr. Murat U\u011fur, grip dahil pek \u00e7ok viral enfeksiyonun kalp damar tutulumu a\u00e7\u0131s\u0131ndan risk yaratt\u0131\u011f\u0131n\u0131n bilindi\u011fini ancak Covid\u2019in, grip vir\u00fcs\u00fc influenzaya g\u00f6re inme riskini 7 kat daha fazla art\u0131rd\u0131\u011f\u0131n\u0131 s\u00f6yledi.<\/p>\n

U\u011fur, pandeminin ilk dalgalar\u0131ndan sonra koronavir\u00fcs\u00fcn damar i\u00e7i endotel tabakas\u0131n\u0131 tuttu\u011funun bilindi\u011fini anlatarak, \u201cDamar i\u00e7i endotel tabakas\u0131 kan i\u00e7in p\u00fcr\u00fczs\u00fcz bir ak\u0131m sa\u011flar. Endotel hasar\u0131 sonras\u0131 buradaki kolesterol plaklar\u0131 birikir, damar t\u0131kan\u0131r ve darl\u0131\u011fa sebep olur. Biz Kovid 19 enfeksiyonunun damar tutulumuna sebep oldu\u011funu biliyorduk. Ge\u00e7ti\u011fimiz haftalarda yay\u0131nlanan bir makalede ise Kovid i\u00e7in yeni bir bulgu saptand\u0131. Bu \u00e7al\u0131\u015fmada, koroner arterlerde yani kalp damarlar\u0131nda, otopsi serilerindeki tutulum kan\u0131tland\u0131. V\u00fccudumuzda vir\u00fcsle sava\u015fta makrofajlar\u0131 kullan\u0131r\u0131z. Makrofajlar, ayn\u0131 zamanda v\u00fccuttan kolesterol\u00fc uzakla\u015ft\u0131rmaya yararlar. Kolesterol ile y\u00fckl\u00fc olan makrofajlara ise \u2018k\u00f6p\u00fck h\u00fccresi\u2019 deniyor. Bu \u00e7al\u0131\u015fmaya g\u00f6re k\u00f6p\u00fck h\u00fccre dedi\u011fimiz bu makrofajlar, direkt vir\u00fcsler taraf\u0131ndan sald\u0131r\u0131ya u\u011fruyor ve enfekte ediliyor; damar i\u00e7indeki kolesterol plaklar\u0131nda \u00e7o\u011falarak, inflamasyonu tetikliyor. Otopsi serilerinde, kardiyak tutulum kan\u0131tlanm\u0131\u015f hastalar\u0131n kalp damarlar\u0131 incelenerek buradaki kolesterol plaklar\u0131nda vir\u00fcs\u00fcn varl\u0131\u011f\u0131 kan\u0131tlanm\u0131\u015f” dedi.<\/p>\n

Ara\u015ft\u0131rman\u0131n, kolesterol y\u00fckl\u00fc damarlar\u0131n vir\u00fcsle enfeksiyona daha a\u00e7\u0131k hale geldi\u011finin ispatland\u0131\u011f\u0131n\u0131 da kaydeden Prof. Dr. U\u011fur, s\u00f6zlerini \u015f\u00f6yle s\u00fcrd\u00fcrd\u00fc: \u201cBu \u00e7al\u0131\u015fmaya g\u00f6re enfekte olan damarlardaki inflamasyonun da bir y\u0131l s\u00fcresince devam etti\u011fi, dolay\u0131s\u0131yla Covid 19 enfeksiyondan sonra en az\u0131ndan bu \u00e7al\u0131\u015fmaya g\u00f6re bir y\u0131l s\u00fcreyle olu\u015fan kalp krizlerinin, inmelerin sorumlusunun enfeksiyon oldu\u011funu s\u00f6yleyebiliriz. Yani vir\u00fcs\u00fcn enfekte etti\u011fi makrofaj plaklar\u0131, kolesterol plaklar\u0131n\u0131n olu\u015fumunu art\u0131r\u0131yor ve bu kolesterol plaklar\u0131ndaki ani kopu\u015flar da kalp krizine veya inmelere sebep olabiliyor.”<\/p>\n

B\u00fct\u00fcn viral enfeksiyonlar\u0131n hayat\u0131m\u0131z\u0131 tehdit edebilecek kalp damar olaylar\u0131 veya n\u00f6rolojik etkilerinin olabilece\u011fine de vurgu yapan Prof. Dr. U\u011fur, Covid 19\u2019un grip vir\u00fcs\u00fc influenzaya g\u00f6re bu riski 7 kat art\u0131rd\u0131\u011f\u0131na dikkat \u00e7ekti ve \u015funlar\u0131 s\u00f6yledi: \u201cBu nedenle \u00e7evremizde Covid 19 enfeksiyonu olsun veya olmas\u0131n, herhangi bir enfeksiyon d\u00f6nemi, buna influenza da dahil, gerekli tedbirlerimizi almak asl\u0131nda bizim kendi sa\u011fl\u0131\u011f\u0131m\u0131z\u0131 korumak a\u00e7\u0131s\u0131ndan \u00e7ok \u00f6nemli.<\/p>\n

\u00dclkemizde kolesterol de\u011ferleri y\u00fcksek hasta say\u0131m\u0131z ve kalp damar hastal\u0131klar\u0131n\u0131n yayg\u0131nl\u0131\u011f\u0131 da olduk\u00e7a y\u00fcksek. Enfeksiyon sonras\u0131 uzun d\u00f6nemde kardiyovask\u00fcler olay veya inme riskini azaltmak i\u00e7in hastalar\u0131m\u0131z\u0131n kardiyak risk a\u00e7\u0131s\u0131ndan mutlaka kontrol edilmesi gerekiyor. \u00f6zellikle ailesinde kalp hastal\u0131\u011f\u0131 olan veya bilinen kalp hastal\u0131\u011f\u0131, hipertansiyonu, \u015fekeri, kolesterol\u00fc olan ki\u015filer mutlaka daha yak\u0131ndan takip edilmeli. Kolesterol\u00fc d\u00fc\u015f\u00fcr\u00fcc\u00fc tedbirlerin al\u0131nmas\u0131, bunun en ba\u015f\u0131nda d\u00fczenli egzersiz, sa\u011fl\u0131kl\u0131 beslenmeye uyulmas\u0131 gerekiyor. Daha ileri seviyelerde gerekirse medikal tedavi de buna eklenebilir.<\/p>\n

Bu \u00e7al\u0131\u015fmada, May\u0131s 2020 ile May\u0131s 2021 aras\u0131nda, yani birinci dalgadaki hastalar incelenmi\u015f. Dolay\u0131s\u0131yla sadece pandeminin ilk aya\u011f\u0131ndaki enfeksiyon, yani mutasyon ge\u00e7irmemi\u015f vir\u00fcs\u00fcn vir\u00fclans\u0131ndan (bula\u015fma g\u00fcc\u00fc) bahsedebiliriz. Yeni vir\u00fcste bu kadar kalp damar tutulumu oluyor mu, bunu zaman g\u00f6sterecek. Fakat yine de bizlerin tedbiri elden b\u0131rakmamam\u0131z ve Covid sonras\u0131 kardiyak a\u00e7\u0131dan takiplerimizi mutlaka yapt\u0131rmam\u0131z gerekiyor.”<\/p>\n","protected":false},"excerpt":{"rendered":"

(The Turkish Post) – Ge\u00e7ti\u011fimiz g\u00fcnlerde d\u00fcnyan\u0131n en sayg\u0131n t\u0131p dergilerinden Nature Cardiovascular Research\u2019da yer alan bir \u00e7al\u0131\u015fma, korona vir\u00fcs\u00fc enfeksiyonunun sadece kalp damarlar\u0131n\u0131 tutmakla yetinmedi\u011fi, \u00f6zellikle kolesterol plaklar\u0131na ve kolesterolle sava\u015fan h\u00fccrelere bula\u015farak onlar\u0131 rezervuar olarak kulland\u0131\u011f\u0131n\u0131; bunun da kolesterol\u00fc y\u00fcksek olanlarda Covid enfeksiyonu sonras\u0131 artm\u0131\u015f kalp krizi ve inme riskinin 1 y\u0131la kadar […]<\/p>\n","protected":false},"author":9,"featured_media":31838,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jnews-multi-image_gallery":[],"jnews_single_post":{"source_name":"Gazeteduvar","source_url":"https:\/\/www.gazeteduvar.com.tr\/otopsi-incelemeleri-ortaya-cikardi-kalp-krizi-ve-inme-riskini-artiriyor-galeri-1641290","via_name":"","via_url":"","override_template":"0","override":[{"template":"1","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"topbottom","share_float_style":"share-monocrhome","show_share_counter":"0","show_view_counter":"0","show_featured":"1","show_post_meta":"1","show_post_author":"0","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"0","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"1","zoom_button_out_step":"4","zoom_button_in_step":"4","show_post_tag":"1","show_prev_next_post":"0","show_popup_post":"1","number_popup_post":"2","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-715","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"107","hide":""},"jnews_override_bookmark_settings":{"override_bookmark_button":"0","override_show_bookmark_button":"0"},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[107,1],"tags":[152,8169,2744,315],"class_list":["post-31837","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yasam","category-son-haberler","tag-covid-19","tag-inme","tag-kalp-krizi","tag-ust-manset"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/31837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/comments?post=31837"}],"version-history":[{"count":0,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/31837\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media\/31838"}],"wp:attachment":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media?parent=31837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/categories?post=31837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/tags?post=31837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}