{"id":27666,"date":"2023-09-15T13:25:37","date_gmt":"2023-09-15T10:25:37","guid":{"rendered":"https:\/\/www.turkishpost.net\/ar\/?p=27666"},"modified":"2023-09-17T14:54:38","modified_gmt":"2023-09-17T11:54:38","slug":"alzheimerda-beyin-hucrelerinin-nasil-oldugu-kesfedildi","status":"publish","type":"post","link":"https:\/\/www.turkishpost.net\/ar\/alzheimerda-beyin-hucrelerinin-nasil-oldugu-kesfedildi\/","title":{"rendered":"Alzheimer’da beyin h\u00fccrelerinin nas\u0131l \u00f6ld\u00fc\u011f\u00fc ke\u015ffedildi"},"content":{"rendered":"

(The Turkish Post) –<\/strong> \u0130ngiltere ve Bel\u00e7ika’daki bilim insanlar\u0131 Alzheimer hastal\u0131\u011f\u0131nda beyin h\u00fccrelerinin nas\u0131l \u00f6ld\u00fc\u011f\u00fcn\u00fc bulduklar\u0131n\u0131 d\u00fc\u015f\u00fcn\u00fcyor. Bu, onlarca y\u0131ld\u0131r bir gizem ve bilimsel tart\u0131\u015fma kayna\u011f\u0131 olmu\u015ftu.<\/p>\n

Ancak hakemli bilimsel dergi Science’ta ara\u015ft\u0131rmas\u0131 yay\u0131nlanan ekip, beyinde biriken anormal proteinleri bir t\u00fcr h\u00fccresel intihar olan “nekroptoz” ile ili\u015fkilendirdi. Bulgular, hastal\u0131\u011f\u0131n tedavisi i\u00e7in yeni fikirler verdi\u011fi i\u00e7in “harika” ve “heyecan verici” olarak nitelendirildi.<\/p>\n

Haf\u0131za kayb\u0131 da dahil olmak \u00fczere Alzheimer belirtililerine yol a\u00e7an \u015fey n\u00f6ron ad\u0131 verilen beyin h\u00fccrelerinin kayb\u0131d\u0131r. Hastal\u0131\u011fa yakalanm\u0131\u015f ki\u015filerin beyinlerinin i\u00e7ine bak\u0131ld\u0131\u011f\u0131nda “amiloid” ve “tau” ad\u0131 verilen anormal proteinlerin birikti\u011fini g\u00f6r\u00fcl\u00fcr. Ancak bilim insanlar\u0131 hastal\u0131\u011f\u0131n bu temel \u00f6zellikleri aras\u0131ndaki noktalar\u0131 birle\u015ftirememi\u015fti.<\/p>\n

UZUN ZAMANDIR BEKLENEN \u0130PU\u00c7LARI<\/strong><\/p>\n

BBC’de yer alan habere g\u00f6re, \u0130ngiltere’deki University College London Demans Ara\u015ft\u0131rma Enstit\u00fcs\u00fc ve Bel\u00e7ika’daki KU Leuven’den ara\u015ft\u0131rmac\u0131lar \u015fimdi bunun ger\u00e7ekle\u015fti\u011fini d\u00fc\u015f\u00fcn\u00fcyor. N\u00f6ronlar aras\u0131ndaki bo\u015fluklarda anormal amiloid birikmeye ba\u015flad\u0131\u011f\u0131n\u0131 ve bunun da n\u00f6ronlar\u0131n ho\u015flanmad\u0131\u011f\u0131 beyin iltihab\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyorlar. Bu da n\u00f6ronlar\u0131n (beyin h\u00fccrelerinin) i\u00e7 kimyas\u0131n\u0131 de\u011fi\u015ftirmeye ba\u015fl\u0131yor.<\/p>\n

Bunun sonucunda tau yumaklar\u0131 ortaya \u00e7\u0131kar ve beyin h\u00fccreleri nekroptoz yoluyla \u00f6l\u00fcm\u00fc tetikleyen belirli bir molek\u00fcl (MEG3 olarak adland\u0131r\u0131l\u0131r) \u00fcretmeye ba\u015flar. Nekroptoz, v\u00fccudumuzun normalde istenmeyen h\u00fccreleri temizlemek i\u00e7in kulland\u0131\u011f\u0131 y\u00f6ntemlerden biridir. Ekip MEG3’\u00fc bloke edebildi\u011finde beyin h\u00fccreleri hayatta kald\u0131.<\/p>\n

\u0130ngiltere Demans Ara\u015ft\u0131rma Enstit\u00fcs\u00fc’nden ara\u015ft\u0131rmac\u0131 Prof Bart De Strooper BBC’ye yapt\u0131\u011f\u0131 a\u00e7\u0131klamada “Bu \u00e7ok \u00f6nemli ve ilgin\u00e7 bir bulgu” dedi.\u0130lk kez Alzheimer hastal\u0131\u011f\u0131nda n\u00f6ronlar\u0131n nas\u0131l ve neden \u00f6ld\u00fc\u011f\u00fcne dair bir ipucu elde ediyoruz. Bu konuda 30-40 y\u0131ld\u0131r pek \u00e7ok spek\u00fclasyon yap\u0131ld\u0131 ama kimse mekanizmalar\u0131 tam olarak belirleyemedi” dedi.<\/p>\n

GELECEKTE ALZHEIMER’I DURDURACAK YEN\u0130 TEDAV\u0130LER\u0130N \u00d6N\u00dcN\u00dc A\u00c7AB\u0130L\u0130R<\/strong><\/p>\n

Ara\u015ft\u0131rma sonu\u00e7lar\u0131 insan beyin h\u00fccrelerinin geneti\u011fi de\u011fi\u015ftirilmi\u015f farelerin beyinlerine nakledildi\u011fi deneylerden geldi. Hayvanlar b\u00fcy\u00fck miktarlarda anormal amiloid \u00fcretecek \u015fekilde programland\u0131. Amiloidi beyinden uzakla\u015ft\u0131ran ila\u00e7lar\u0131n geli\u015ftirilmesinde son zamanlarda ba\u015far\u0131 sa\u011fland\u0131 ve bunlar beyin h\u00fccrelerinin y\u0131k\u0131m\u0131n\u0131 yava\u015flatan ilk tedaviler oldu. Prof De Strooper, MEG3 molek\u00fcl\u00fcn\u00fcn bloke edilmesinin beyin h\u00fccresi \u00f6l\u00fcm\u00fcn\u00fc geciktirebilece\u011finin ke\u015ffinin “yepyeni bir ila\u00e7 geli\u015ftirme hatt\u0131na” yol a\u00e7abilece\u011fini s\u00f6yl\u00fcyor. Ancak bunun i\u00e7in y\u0131llarca ara\u015ft\u0131rma yap\u0131lmas\u0131 gerekecek.<\/p>\n

Alzheimer’s Research UK’den Dr. Susan Kohlhaas da bulgular\u0131n “heyecan verici” oldu\u011funu ancak hen\u00fcz erken bir a\u015famada bulundu\u011funu s\u00f6yledi. “Bu ke\u015fif \u00f6nemli \u00e7\u00fcnk\u00fc Alzheimer hastal\u0131\u011f\u0131nda daha \u00f6nce anlamad\u0131\u011f\u0131m\u0131z yeni h\u00fccre \u00f6l\u00fcm\u00fc mekanizmalar\u0131na i\u015faret ediyor ve gelecekte hastal\u0131\u011f\u0131n ilerlemesini yava\u015flatacak, hatta durduracak yeni tedavilerin \u00f6n\u00fcn\u00fc a\u00e7abilir” dedi.<\/p>\n","protected":false},"excerpt":{"rendered":"

(The Turkish Post) – \u0130ngiltere ve Bel\u00e7ika’daki bilim insanlar\u0131 Alzheimer hastal\u0131\u011f\u0131nda beyin h\u00fccrelerinin nas\u0131l \u00f6ld\u00fc\u011f\u00fcn\u00fc bulduklar\u0131n\u0131 d\u00fc\u015f\u00fcn\u00fcyor. Bu, onlarca y\u0131ld\u0131r bir gizem ve bilimsel tart\u0131\u015fma kayna\u011f\u0131 olmu\u015ftu. Ancak hakemli bilimsel dergi Science’ta ara\u015ft\u0131rmas\u0131 yay\u0131nlanan ekip, beyinde biriken anormal proteinleri bir t\u00fcr h\u00fccresel intihar olan “nekroptoz” ile ili\u015fkilendirdi. Bulgular, hastal\u0131\u011f\u0131n tedavisi i\u00e7in yeni fikirler verdi\u011fi i\u00e7in […]<\/p>\n","protected":false},"author":8,"featured_media":27667,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jnews-multi-image_gallery":[],"jnews_single_post":{"source_name":"Art\u0131 Ger\u00e7ek","source_url":"https:\/\/artigercek.com\/saglik\/alzheimer-265318h","via_name":"","via_url":"","override_template":"0","override":[{"template":"1","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"topbottom","share_float_style":"share-monocrhome","show_share_counter":"0","show_view_counter":"0","show_featured":"1","show_post_meta":"1","show_post_author":"0","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"0","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"1","zoom_button_out_step":"4","zoom_button_in_step":"4","show_post_tag":"1","show_prev_next_post":"0","show_popup_post":"1","number_popup_post":"2","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-715","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"107","hide":""},"jnews_override_bookmark_settings":{"override_bookmark_button":"0","override_show_bookmark_button":"0"},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[107,1],"tags":[5127,2430,7359,5742,1422],"class_list":["post-27666","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yasam","category-son-haberler","tag-alzheimer","tag-beyin","tag-hucreleri","tag-olum","tag-slider-manset"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/27666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/comments?post=27666"}],"version-history":[{"count":0,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/27666\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media\/27667"}],"wp:attachment":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media?parent=27666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/categories?post=27666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/tags?post=27666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}