{"id":18478,"date":"2023-08-03T13:41:24","date_gmt":"2023-08-03T10:41:24","guid":{"rendered":"https:\/\/www.turkishpost.net\/ar\/?p=18478"},"modified":"2023-08-03T16:05:08","modified_gmt":"2023-08-03T13:05:08","slug":"kanser-tedavisinde-devrimsel-gelisme-tumorleri-olduren-hap-gelistirildi","status":"publish","type":"post","link":"https:\/\/www.turkishpost.net\/ar\/kanser-tedavisinde-devrimsel-gelisme-tumorleri-olduren-hap-gelistirildi\/","title":{"rendered":"Kanser tedavisinde devrimsel geli\u015fme: T\u00fcm\u00f6rleri \u00f6ld\u00fcren hap geli\u015ftirildi"},"content":{"rendered":"

(The Turkish Post) –<\/strong> Son d\u00f6nemlerde bilimsel ke\u015fifler ve at\u0131l\u0131mlar iyice h\u0131z kazand\u0131. Son olarak yirmi y\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir geli\u015ftirilen AOH1996 ilac\u0131, kanser tedavisinde adeta bir devrim yaratman\u0131n e\u015fi\u011finde.<\/p>\n

KANSERDE \u00c7I\u011eIR A\u00c7AN HAPIN ‘T\u00dcM\u00d6RLER\u0130 \u00d6LD\u00dcRD\u00dc\u011e\u00dc’ ORTAYA \u00c7IKTI<\/strong><\/p>\n

ABD’nin \u00f6nde gelen bir hastanesindeki bilim insanlar\u0131, solid t\u00fcm\u00f6rleri “hedefe y\u00f6nelik kemoterapi” yoluyla \u00f6ld\u00fcren bir “kanser \u00f6ld\u00fcr\u00fcc\u00fc hap” geli\u015ftirdi. Bilim insanlar\u0131, kemoterapi ilac\u0131n\u0131n sa\u011fl\u0131kl\u0131 h\u00fccreleri etkilemedi\u011fini a\u00e7\u0131klad\u0131. AOH1996 olarak adland\u0131r\u0131lan ila\u00e7, 1996 do\u011fumlu Anna Olivia Healy ad\u0131nda, nadir g\u00f6r\u00fclen bir \u00e7ocukluk \u00e7a\u011f\u0131 kanseri olan n\u00f6roblastom te\u015fhisi konulduktan sonra hen\u00fcz dokuz ya\u015f\u0131ndayken \u00f6len bir \u00e7ocu\u011fun ad\u0131n\u0131 ta\u015f\u0131yor.<\/p>\n

Anna’n\u0131n \u00f6l\u00fcm\u00fc belki de milyonlar\u0131n kurtulmas\u0131n\u0131 sa\u011flayacak k\u0131v\u0131lc\u0131m\u0131 ate\u015fledi. \u00d6l\u00fcm\u00fcnden bu yana Anna\u2019n\u0131n ailesi City of Hope hastanesinde AOH1996’y\u0131 geli\u015ftirmek i\u00e7in 20 y\u0131l\u0131n\u0131 harcayan Profes\u00f6r Linda Malkas’a para ba\u011f\u0131\u015fl\u0131yor. Ve \u015fimdi, umut verici geli\u015fmelere tan\u0131kl\u0131k ediyoruz.<\/p>\n

KANSER TEDAV\u0130S\u0130NDE ATILIM<\/strong><\/p>\n

Profes\u00f6r Linda Malkas ve ekibi, Anna’n\u0131n \u00f6l\u00fcm\u00fcne yol a\u00e7an kanser de dahil olmak \u00fczere t\u00fcm kanserlerdeki bir proteini hedef alan ilac\u0131 geli\u015ftirmek i\u00e7in yirmi y\u0131l harcad\u0131. Proliferating cell nuclear antigen (PCNA) adl\u0131 bu proteinin kanserli varyant\u0131 hedefleniyor. Mutasyona u\u011fram\u0131\u015f haliyle PCNA, DNA replikasyonuna ve kanserli h\u00fccrelerin onar\u0131m\u0131na yard\u0131mc\u0131 olarak t\u00fcm\u00f6rleri b\u00fcy\u00fcmeye te\u015fvik ediyor.<\/p>\n

T\u00dcRK PROFES\u00d6R\u00dcN “\u015eEFFAF G\u00d6R\u00dcNT\u00dcLEME” TEKNOLOJ\u0130S\u0130 SES GET\u0130RD\u0130<\/strong><\/p>\n

Prof Malkas ve Amerika Birle\u015fik Devletleri’nin en b\u00fcy\u00fck kanser ara\u015ft\u0131rma ve tedavi kurulu\u015flar\u0131ndan biri olan Kaliforniya’daki City of Hope’taki ekibi, hedefe y\u00f6nelik kemoterapilerinin klinik \u00f6ncesi ara\u015ft\u0131rmalarda t\u00fcm solid t\u00fcm\u00f6rleri “yok etti\u011fini” s\u00f6yledi. Ara\u015ft\u0131rma ekibi taraf\u0131ndan geli\u015ftirilen protein, “\u00f6nemli bir havayolu merkezini kapatan ve sadece kanser h\u00fccresi ta\u015f\u0131yan u\u00e7aklarda t\u00fcm u\u00e7u\u015flar\u0131 durduran bir kar f\u0131rt\u0131nas\u0131na” benzetiliyor.<\/p>\n

70\u2019TEN FAZLA KANSER\u0130 ENGELL\u0130YOR<\/strong><\/p>\n

Kanserde \u00e7\u0131\u011f\u0131r a\u00e7an hap\u0131n ‘t\u00fcm\u00f6rleri \u00f6ld\u00fcrd\u00fc\u011f\u00fc’ ortaya \u00e7\u0131kt\u0131<\/p>\n

Hakemli Cell Chemical Biology dergisinde yay\u0131nlanan \u00e7al\u0131\u015fmada AOH1996, 70’ten fazla h\u00fccre hatt\u0131nda test edilmi\u015f ve normal h\u00fccre \u00fcreme d\u00f6ng\u00fcs\u00fcn\u00fc bozarak kanser h\u00fccrelerini se\u00e7ici olarak \u00f6ld\u00fcrd\u00fc\u011f\u00fc, ancak sa\u011fl\u0131kl\u0131 k\u00f6k h\u00fccrelerin \u00fcreme d\u00f6ng\u00fcs\u00fcn\u00fc kesintiye u\u011fratmad\u0131\u011f\u0131 bulundu. Klinik \u00f6ncesi \u00e7al\u0131\u015fmalar ilac\u0131n, meme, prostat, beyin, yumurtal\u0131k, rahim a\u011fz\u0131, deri ve akci\u011fer kanserlerinden t\u00fcretilen h\u00fccrelerin tedavisinde etkili oldu\u011funu g\u00f6steriyor.<\/p>\n

\u00d6te yandan ilac\u0131n yayg\u0131n olarak kullan\u0131labilmesi i\u00e7in hala titiz g\u00fcvenlik ve etkinlik testlerinden ve b\u00fcy\u00fck \u00f6l\u00e7ekli klinik deneylerden ge\u00e7mesi gerekiyor. Ancak ilk hasta ekim ay\u0131nda potansiyel kanser \u00f6nleyici hap\u0131 ald\u0131 ve birinci a\u015fama klinik \u00e7al\u0131\u015fma halen devam ediyor ve en az iki y\u0131l s\u00fcrmesi bekleniyor. Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca hayvan \u00e7al\u0131\u015fmalar\u0131nda ilac\u0131n i\u015fe yaramas\u0131n\u0131 sa\u011flayan mekanizmalar\u0131 da incelemeye devam ediyor.<\/p>\n

Prof Malkas yapt\u0131\u011f\u0131 a\u00e7\u0131klamada \u015funlar\u0131 s\u00f6yledi: “PCNA, birden fazla u\u00e7ak kap\u0131s\u0131 i\u00e7eren b\u00fcy\u00fck bir havayolu terminal merkezi gibidir. Veriler, PCNA’n\u0131n kanser h\u00fccrelerinde benzersiz bir \u015fekilde de\u011fi\u015fti\u011fini g\u00f6steriyor ve bu ger\u00e7ek, kanser h\u00fccrelerinde yaln\u0131zca PCNA formunu hedefleyen bir ila\u00e7 tasarlamam\u0131z\u0131 sa\u011flad\u0131” dedi.<\/p>\n

\u00c7al\u0131\u015fman\u0131n ba\u015fyazar\u0131 Long Gu ise \u015funlar\u0131 s\u00f6yledi: “Hi\u00e7 kimse PCNA’y\u0131 tedavi edici bir ila\u00e7 olarak hedeflemedi \u00e7\u00fcnk\u00fc PCNA ‘tedavi edilemez’ olarak g\u00f6r\u00fcl\u00fcyordu, ancak City of Hope’un zorlu bir protein hedefi i\u00e7in ara\u015ft\u0131rma ama\u00e7l\u0131 bir ila\u00e7 geli\u015ftirmeyi ba\u015fard\u0131\u011f\u0131 a\u00e7\u0131k.” Ara\u015ft\u0131rma ama\u00e7l\u0131 kemoterap\u00f6tik \u015fu anda City of Hope’daki insanlarda 1. Faz klinik denemesinde bulunuyor ve ilerleyen d\u00f6nemlerde sonu\u00e7lar\u0131n daha da g\u00fc\u00e7lendirilerek 2. Faz klinik deneylere ge\u00e7ilmesi hedefleniyor.<\/p>\n","protected":false},"excerpt":{"rendered":"

(The Turkish Post) – Son d\u00f6nemlerde bilimsel ke\u015fifler ve at\u0131l\u0131mlar iyice h\u0131z kazand\u0131. Son olarak yirmi y\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir geli\u015ftirilen AOH1996 ilac\u0131, kanser tedavisinde adeta bir devrim yaratman\u0131n e\u015fi\u011finde. KANSERDE \u00c7I\u011eIR A\u00c7AN HAPIN ‘T\u00dcM\u00d6RLER\u0130 \u00d6LD\u00dcRD\u00dc\u011e\u00dc’ ORTAYA \u00c7IKTI ABD’nin \u00f6nde gelen bir hastanesindeki bilim insanlar\u0131, solid t\u00fcm\u00f6rleri “hedefe y\u00f6nelik kemoterapi” yoluyla \u00f6ld\u00fcren bir “kanser \u00f6ld\u00fcr\u00fcc\u00fc […]<\/p>\n","protected":false},"author":9,"featured_media":18487,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jnews-multi-image_gallery":[],"jnews_single_post":{"source_name":"Donan\u0131mhaber","source_url":"https:\/\/www.donanimhaber.com\/kanserde-cigir-acan-hapin-tumorleri-oldurdugu-ortaya-cikti--166423","via_name":"","via_url":"","override_template":"0","override":[{"template":"1","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"topbottom","share_float_style":"share-monocrhome","show_share_counter":"0","show_view_counter":"0","show_featured":"1","show_post_meta":"1","show_post_author":"0","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"0","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"1","zoom_button_out_step":"4","zoom_button_in_step":"4","show_post_tag":"1","show_prev_next_post":"0","show_popup_post":"1","number_popup_post":"2","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-715","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"107","hide":""},"jnews_override_bookmark_settings":{"override_bookmark_button":"0","override_show_bookmark_button":"0"},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[107,1],"tags":[5609,1434,5608,5610,1422,1607],"class_list":["post-18478","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yasam","category-son-haberler","tag-akciger-kanseri","tag-hucre","tag-kanser-tedavisi","tag-saglik-klinigi","tag-slider-manset","tag-tedavi"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/18478","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/comments?post=18478"}],"version-history":[{"count":0,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/18478\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media\/18487"}],"wp:attachment":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media?parent=18478"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/categories?post=18478"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/tags?post=18478"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}