{"id":11867,"date":"2023-06-02T16:53:28","date_gmt":"2023-06-02T13:53:28","guid":{"rendered":"https:\/\/www.turkishpost.net\/ar\/?p=11867"},"modified":"2023-06-02T16:53:28","modified_gmt":"2023-06-02T13:53:28","slug":"psikiyatride-devrim-yaratan-hikaye-katatonik-halde-20-yil-kalan-kadin-uyandi","status":"publish","type":"post","link":"https:\/\/www.turkishpost.net\/ar\/psikiyatride-devrim-yaratan-hikaye-katatonik-halde-20-yil-kalan-kadin-uyandi\/","title":{"rendered":"Psikiyatride devrim yaratan hikaye: Katatonik halde 20 y\u0131l kalan kad\u0131n uyand\u0131"},"content":{"rendered":"

(The Turkish Post) –<\/strong> ABD’de katatonik halde 20 y\u0131l boyunca kalan kad\u0131n kendine geldi. April Burrell’i tedavi eden doktorlar, kad\u0131n\u0131n asl\u0131nda katatonik \u015fizofreniden de\u011fil lupustan mustarip oldu\u011funu belirledi.<\/p>\n

Bu tespit, \u015fizofreni gibi psikiyatrik rahats\u0131zl\u0131klara sahip baz\u0131 hastalar\u0131n asl\u0131nda beyne sald\u0131ran bu otoimm\u00fcn hastal\u0131ktan mustarip olabilece\u011fini ortaya koydu. Psikaytri d\u00fcnyas\u0131nda bir devrim yapan uzmanlar, d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131na bulgular\u0131n\u0131 g\u00f6nderip di\u011fer ara\u015ft\u0131rmac\u0131lar\u0131 bilgilendirdi.<\/p>\n

Burrell hasta olmadan \u00f6nce Maryland Eastern Shore \u00dcniversitesi’nde muhasebe b\u00f6l\u00fcm\u00fcnde okuyan d\u0131\u015fa d\u00f6n\u00fck ve ba\u015far\u0131l\u0131 bir \u00f6\u011frenciydi. Talihsiz kad\u0131n, 1995’te 21 ya\u015f\u0131ndayken ba\u015f\u0131ndan ge\u00e7en travmatik bir olay\u0131n ard\u0131ndan psikoza girdi. G\u00f6rsel ve i\u015fitsel hal\u00fcsinasyonlar ya\u015famaya ba\u015flad\u0131. Washington Post (WP) kad\u0131n\u0131n ba\u015f\u0131ndan ge\u00e7enleri mahremiyet sebebiyle a\u00e7\u0131klamad\u0131.<\/p>\n

Art\u0131k ileti\u015fim kuramayan ve banyo bile yapamayan Burrell’e, psikiyatri hastanesinde birka\u00e7 ay kald\u0131ktan sonra katatonik \u015fizofreni te\u015fhisi kondu. D\u00fcnya n\u00fcfusunun yakla\u015f\u0131k y\u00fczde 1’ini etkileyen bu rahats\u0131zl\u0131kta hastalar motor hareketlerde azalma, konu\u015fmama, kar\u015f\u0131dakinin s\u00f6ylediklerini ve hareketlerini tekrarlama, kaslarda kat\u0131l\u0131k, hareket ettirmeye kar\u015f\u0131 diren\u00e7 gibi belirtiler g\u00f6steriyor.<\/p>\n

Ailesi, Burrell’e bakmak i\u00e7in ellerinden geleni yapt\u0131. Ancak s\u00fcrekli bak\u0131ma muhta\u00e7 olan kad\u0131n, 2000’de New York’taki bir psikiyatri merkezine yat\u0131r\u0131ld\u0131. Gen\u00e7 kad\u0131n kendi psikoz d\u00fcnyas\u0131na hapsoldu. Ailesini bile tan\u0131yamaz hale geldi.<\/p>\n

“Dejavu ya\u015fam\u0131\u015f gibiydim”<\/strong><\/h4>\n

Ayn\u0131 psikiyatri merkezinde o y\u0131llarda t\u0131p \u00f6\u011frencisi olan Sander Markx da staj yap\u0131yordu. Markx, yakla\u015f\u0131k 20 y\u0131l sonra kendi laboratuar\u0131n\u0131 a\u00e7t\u0131\u011f\u0131nda \u015fans eseri stajyerlerden biri, Markx’a Burrell’den bahsetti. Markx, 2018’deki sohbete dair \u015f\u00f6yle konu\u015ftu: “Hikayeyi anlatmaya ba\u015flad\u0131\u011f\u0131nda dejavu ya\u015fam\u0131\u015f gibiydim. ‘Ad\u0131 April mi?’ dedim.”<\/p>\n

Psikiyatr Markx, ge\u00e7en onca y\u0131la ve uygulanan tedavilere ra\u011fmen hastan\u0131n durumunun hi\u00e7 iyile\u015fmemesi kar\u015f\u0131s\u0131nda afallad\u0131\u011f\u0131n\u0131 vurgulad\u0131. Bunun ard\u0131ndan 2018’de harekete ge\u00e7en doktor, ailesinden de onay olarak Burrell’i incelemeye koyuldu. N\u00f6ropsikiyatrist, n\u00f6rolog ve n\u00f6roimm\u00fcnologlar\u0131n da aralar\u0131nda yer ald\u0131\u011f\u0131 70 ki\u015filik bir uluslararas\u0131 uzman ekibi topland\u0131.<\/p>\n

Kan tahlili, Burrell’in ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00e7ok say\u0131da antikor \u00fcretti\u011fini ve bunun v\u00fccuda sald\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Beyin taramas\u0131 bu antikorlar\u0131n \u00f6zellikle \u015fizofreni ve psikozla ili\u015fkili \u015fakak loblar\u0131na zarar verdi\u011fini ortaya koydu.<\/p>\n

Hasta kad\u0131n \u015fizofreninin t\u00fcm belirtilerini ta\u015f\u0131sa da ara\u015ft\u0131rma ekibi alt\u0131nda yatan nedenin lupus oldu\u011funa kanaat getirdi. Kelebek hastal\u0131\u011f\u0131 diye de bilinen bu rahats\u0131zl\u0131kta ki\u015finin ba\u011f\u0131\u015f\u0131kl\u0131k sistemi, v\u00fccuttaki doku ve organlara sald\u0131r\u0131yor. Ancak Burrell’de hastal\u0131k sadece beyni etkiliyor gibi g\u00f6r\u00fcn\u00fcyordu.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemine kar\u015f\u0131 koymak i\u00e7in \u00e7al\u0131\u015fmalara ba\u015flad\u0131 ve 6 ay boyunca tedavi uyguland\u0131. Burrell \u00e7ok say\u0131da ila\u00e7 kulland\u0131. Hasta neredeyse hemen iyile\u015fme belirtileri g\u00f6stermeye ba\u015flad\u0131. Ancak bili\u015fsel sorunlar\u0131 atlatmaya ba\u015flasa da psikoz devam etti.<\/p>\n

Markx, bu sebeple ara\u015ft\u0131rma ekibindeki baz\u0131 ki\u015filerin hastay\u0131 psikiyatri merkezine tekrar g\u00f6ndermek istedi\u011fini, kendisinin de ayn\u0131 d\u00f6nemde Hollanda’ya gitmek zorunda oldu\u011funu ve yoklu\u011funda kad\u0131n\u0131n g\u00f6nderilmesinden korktu\u011funu a\u00e7\u0131klad\u0131. Psikiyatr, u\u00e7u\u015funun oldu\u011fu g\u00fcn hastas\u0131n\u0131 son kez ziyaret etti\u011finde bir s\u00fcrprizle kar\u015f\u0131la\u015ft\u0131.<\/p>\n

Zira doktor, Burrell’in katatonik durumda olmad\u0131\u011f\u0131n\u0131, adeta farkl\u0131 bir kad\u0131n g\u00f6rd\u00fc\u011f\u00fcn\u00fc ifade etti: “20 y\u0131ld\u0131r tan\u0131d\u0131\u011f\u0131m ve fazlas\u0131yla hasta g\u00f6rd\u00fc\u011f\u00fcm birine benzemiyordu. Biraz daha yak\u0131ndan bakt\u0131m ve ‘Aman Tanr\u0131m. Bu o’ dedim.”<\/p>\n

2020’de Burrell, psikiyatri hastanesinden taburcu edilecek kadar iyi durumdayd\u0131. Hasta, rehabilitasyon merkezine nakledildi. Burrell’in karde\u015fleri, Kovid-19 pandemisi sebebiyle ertelenen g\u00f6r\u00fc\u015fmelerini ge\u00e7en sene ger\u00e7ekle\u015ftirdi. Abisi Guy Burrell \u015f\u00f6yle konu\u015ftu: “K\u0131z karde\u015fimin eski haline d\u00f6nmesini hep istemi\u015ftim. Oraya geldi\u011finde, onun yepyeni bir insan oldu\u011funu d\u00fc\u015f\u00fcnd\u00fck. Hepimizi tan\u0131yordu. \u00c7ocuklu\u011funa dair farkl\u0131 \u015feyler hat\u0131rl\u0131yordu.”<\/p>\n

Burrell’in, hastal\u0131\u011f\u0131n beynini etkilemeye ba\u015flad\u0131\u011f\u0131 zamana kadar ya\u015fananlar\u0131 hat\u0131rlad\u0131\u011f\u0131 tespit edildi.<\/p>\n

200 hasta belirlendi<\/strong><\/h4>\n

Hastadaki iyile\u015fmenin ard\u0131ndan ara\u015ft\u0131rmac\u0131lar, antikor a\u00e7\u0131s\u0131ndan benzer hastalar\u0131 belirlemek i\u00e7in di\u011fer hastanelerle temasa ge\u00e7ti. Birka\u00e7 ay sonra Devine Cruz adl\u0131 bir hasta bulundu. Hastaya \u00f6nceden \u015fizoaffektif bozukluk, zeka gerili\u011fi ve lupus gibi te\u015fhisler konsa da doktorlar hi\u00e7bir zaman bunlar aras\u0131nda ba\u011flant\u0131 kurmam\u0131\u015ft\u0131.<\/p>\n

Markx ve ekibinin uygulad\u0131\u011f\u0131 tedaviyle 20 ya\u015f\u0131ndaki kad\u0131n iyile\u015fmeye ba\u015flad\u0131. Art\u0131k annesiyle ya\u015fayan Cruz, annesine mutfakta yard\u0131m ediyor, markete gidiyor ve toplu ta\u015f\u0131ma ara\u00e7lar\u0131n\u0131 kullanabiliyor.<\/p>\n

Ara\u015ft\u0131rma ekibi, psikiyatrik sorunlar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131ktan kaynakland\u0131\u011f\u0131 \u00e7ok fazla hasta oldu\u011funu d\u00fc\u015f\u00fcn\u00fcyor. Yetkililer New York’ta benzer durumda olan yakla\u015f\u0131k 200 hasta belirledi.<\/p>\n

D\u00fcnyan\u0131n pek \u00e7ok b\u00f6lgesinde bilim insanlar\u0131 art\u0131k benzer ara\u015ft\u0131rmalar y\u00fcr\u00fcyor. WP, mevcut ara\u015ft\u0131rman\u0131n muhtemelen k\u00fc\u00e7\u00fck bir hasta grubunun i\u015fine yarayaca\u011f\u0131n\u0131 ancak etkisinin psikiyatride te\u015fhis ve tedavi y\u00f6ntemlerini tekrar \u015fekillendirmeye ba\u015flad\u0131\u011f\u0131n\u0131 yazd\u0131.<\/p>\n

Markx \u015f\u00f6yle konu\u015ftu: “Bunlar unutulmu\u015f ruhlar. Bu insanlar\u0131n hayatlar\u0131n\u0131 iyile\u015ftirmekle kalm\u0131yoruz, ayn\u0131 zamanda onlar\u0131 geri d\u00f6nebileceklerini d\u00fc\u015f\u00fcnmedi\u011fim bir yerden geri getiriyoruz.”<\/p>\n

Burrell ve Cruz vakalar\u0131n\u0131n ard\u0131ndan New York’taki Columbia \u00dcniversitesi’nde yer alan SNF Hassas Psikiyatri ve Ak\u0131l Sa\u011fl\u0131\u011f\u0131 Merkezi’ne 75 milyon dolar ba\u011f\u0131\u015fland\u0131. Merkez, hastal\u0131klar\u0131n genetik ve otoimm\u00fcn nedenleriyle ilgili yeni tedaviler geli\u015ftirmeyi ama\u00e7l\u0131yor.<\/p>\n

Markx, Nisan 2023’te a\u00e7\u0131lan bu merkezde yakla\u015f\u0131k 40 hastan\u0131n tedavisine ba\u015flad\u0131\u011f\u0131n\u0131 bildirdi.<\/p>\n

Markx ve ekibinin ara\u015ft\u0131rmas\u0131n\u0131n tam olarak ka\u00e7 hastan\u0131n i\u015fine yarayaca\u011f\u0131 soru i\u015fareti olmaya devam ediyor. WP, ara\u015ft\u0131rman\u0131n hastalar\u0131n beyninde neler olup bitti\u011fini daha iyi anlama potansiyelinin bilim camias\u0131nda heyecan uyand\u0131rd\u0131\u011f\u0131n\u0131 yazd\u0131. Notel T\u0131p \u00d6d\u00fcl\u00fc sahibi Richard Axel, “Bence temel sinirbilimciler olarak art\u0131k hem kavramsal hem de teknolojik a\u00e7\u0131dan katk\u0131 sa\u011flayabilecek bir konumday\u0131z. Bunu yapmak bizim sorumlulu\u011fumuz” dedi.<\/p>\n

Molecular Psychiatry adl\u0131 hakemli bilimsel dergide ge\u00e7en y\u0131l yay\u0131mlanan bir \u00e7al\u0131\u015fmada, otoimm\u00fcn rahats\u0131zl\u0131k ta\u015f\u0131d\u0131\u011f\u0131ndan \u015f\u00fcphelenilen 91 psikiyatri hastas\u0131 belirlendi. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemine uygulanan imm\u00fcnoterapilerin bu hastalara fayda sa\u011flad\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n","protected":false},"excerpt":{"rendered":"

(The Turkish Post) – ABD’de katatonik halde 20 y\u0131l boyunca kalan kad\u0131n kendine geldi. April Burrell’i tedavi eden doktorlar, kad\u0131n\u0131n asl\u0131nda katatonik \u015fizofreniden de\u011fil lupustan mustarip oldu\u011funu belirledi. Bu tespit, \u015fizofreni gibi psikiyatrik rahats\u0131zl\u0131klara sahip baz\u0131 hastalar\u0131n asl\u0131nda beyne sald\u0131ran bu otoimm\u00fcn hastal\u0131ktan mustarip olabilece\u011fini ortaya koydu. Psikaytri d\u00fcnyas\u0131nda bir devrim yapan uzmanlar, d\u00fcnyan\u0131n d\u00f6rt […]<\/p>\n","protected":false},"author":2,"featured_media":11868,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jnews-multi-image_gallery":[],"jnews_single_post":{"source_name":"Independent","source_url":"https:\/\/www.indyturk.com\/node\/636516\/sa\u011flik\/psikiyatride-devrim-yaratan-hikaye-katatonik-halde-20-y\u0131l-kalan-kad\u0131n-uyand\u0131","via_name":"","via_url":"","override_template":"0","override":[{"template":"1","single_blog_custom":"","parallax":"1","fullscreen":"1","layout":"right-sidebar","sidebar":"default-sidebar","second_sidebar":"default-sidebar","sticky_sidebar":"1","share_position":"topbottom","share_float_style":"share-monocrhome","show_share_counter":"0","show_view_counter":"0","show_featured":"1","show_post_meta":"1","show_post_author":"0","show_post_author_image":"1","show_post_date":"1","post_date_format":"default","post_date_format_custom":"Y\/m\/d","show_post_category":"0","show_post_reading_time":"1","post_reading_time_wpm":"300","show_zoom_button":"1","zoom_button_out_step":"4","zoom_button_in_step":"4","show_post_tag":"1","show_prev_next_post":"0","show_popup_post":"1","number_popup_post":"2","show_author_box":"1","show_post_related":"1","show_inline_post_related":"0"}],"override_image_size":"0","image_override":[{"single_post_thumbnail_size":"crop-715","single_post_gallery_size":"crop-500"}],"trending_post":"0","trending_post_position":"meta","trending_post_label":"Trending","sponsored_post":"0","sponsored_post_label":"Sponsored by","sponsored_post_name":"","sponsored_post_url":"","sponsored_post_logo_enable":"0","sponsored_post_logo":"","sponsored_post_desc":"","disable_ad":"0"},"jnews_primary_category":{"id":"107","hide":""},"jnews_override_bookmark_settings":{"override_bookmark_button":"0","override_show_bookmark_button":"0"},"jnews_social_meta":{"fb_title":"","fb_description":"","fb_image":"","twitter_title":"","twitter_description":"","twitter_image":""},"jnews_override_counter":{"override_view_counter":"0","view_counter_number":"0","override_share_counter":"0","share_counter_number":"0","override_like_counter":"0","like_counter_number":"0","override_dislike_counter":"0","dislike_counter_number":"0"},"footnotes":""},"categories":[1,107],"tags":[3581,3582,3583,3584,3585,3580,1422],"class_list":["post-11867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-son-haberler","category-yasam","tag-devrim","tag-katatonik","tag-katatonik-sizofreni","tag-lupus","tag-maryland-eastern-shore-universitesi","tag-psikiyatri","tag-slider-manset"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/11867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/comments?post=11867"}],"version-history":[{"count":0,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/posts\/11867\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media\/11868"}],"wp:attachment":[{"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/media?parent=11867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/categories?post=11867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.turkishpost.net\/ar\/wp-json\/wp\/v2\/tags?post=11867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}